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25048

Aconine

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12-,13+,14-,15?,16+,17-,18?,19-,20+,21+,22+,23-,24?,25-/m1/s1
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Toxicology & Xenobiotic Metabolism|Organ- & System-Specific Toxicity|Neurotoxicity
  • Smiles: CO[C@@H]1C2(C3N4CC)[C@@]([C@@H](OC)C3[C@]([C@@H](O)[C@H](OC)[C@]5(O)[C@@H]6O)(O)[C@]6([H])[C@]2(C5)[H])([H])[C@](COC)(C4)[C@H](O)C1
  • Inchikey: SQMGCPHFHQGPIF-FGBFNOOXSA-N
  • Cas Number: 509-20-6
  • Formulation: A crystalline solid
  • Item Origin: Plant/Aconitum carmichaelii Debx
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C25H41NO9
  • Formula Weight: 499.6
  • Shelf Life Days: 1460

DESCRIPTION

An active metabolite of aconitine; inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay; inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells; toxic to mice at 120 mg/kg; induces flaccid paralysis and toxicity in rats (TD50 = 1.5 μmol/animal; LD50 = 1.7 μmol/animal)