Human CTLA-4 / CD152 Protein, Twin-Strep Tag

DESCRIPTION

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

DETAILS

Tag: C-Twin-Strep
Host: HEK293
Size: 250ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 85%
Source: Human CTLA-4 Protein, Twin-Strep Tag (CT4-H5284) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1).
Storage: -20℃
Category: Immune Checkpoint Proteins
Molecule: CTLA-4
Accession: NP_005205.2
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ala 37 - Phe 162
Swiss-prot: P16410-1
Package Size: 250ug*1
Characteristics: This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 16.5 kDa. The protein migrates as 20-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 16.5 kDa
Shipping Condition: RT
Species Reactivity: Human
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