Biotinylated Human IL-31 Protein, His,Avitag™ (MALS verified)

DESCRIPTION

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

DETAILS

Tag: N-10×His & C-Avi
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Biotinylated Human IL-31 Protein, His,Avitag (IL1-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Thr 164 (Accession # Q6EBC2-1).
Storage: -20℃
Category: MABSol® Biotin Labeled Proteins
Molecule: IL-31
Conjugate: Biotin-labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ser 24 - Thr 164
Swiss-prot: Q6EBC2-1
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the N-terminus and an Avi tag (Avitag™) at the C-terminus. The protein has a calculated MW of 19.9 kDa. As a result of glycosylation, the protein migrates as 27-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition, and Q6EBC2-1 under non-reducing (NR) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 19.9 kDa
Shipping Condition: RT
Species Reactivity: Human
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