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HA721108

Scientist.com Supplier

Anti-NTH1 Antibody [JE65-02]

HuaBio

DESCRIPTION

Endonuclease III-like protein 1 is an enzyme that in humans is encoded by the NTHL1 gene. As reviewed by Li et al. NTHL1 is a bifunctional DNA glycosylase that has an associated beta-elimination activity. NTHL1 is usually involved in removing oxidative pyrimidine lesions through base excision repair. NTHL1 catalyses the first step in base excision repair. It cleaves the N-glycosylic bond between the damaged base and its associated sugar residue and then cleaves the phosphodiester bond 3' to the AP site, leaving a 3'-unsaturated aldehyde after beta-elimination and a 5'-phosphate at the termini of the repair gap. Low expression of NTHL1 is associated with initiation and development of astrocytoma. Low expression of NTHL1 is also found in follicular thyroid tumors. A germ line homozygous mutation in NTHL1 causes a cancer susceptibility syndrome similar to Lynch syndrome.

DETAILS

  • Host: Rabbit
  • Type: Primary
  • Uniprot: SwissProt: P78549 Human
  • Clone Id: JE65-02
  • Clonality: Recombinant Rabbit monoclonal Antibody
  • Conjugate: Non-conjugated
  • Alias Names: Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase antibody DNA glycoslyase/AP lyase antibody Endonuclease III like protein 1 antibody Endonuclease III-like protein 1 antibody hNTH1 antibody NTH 1 antibody nth endonuclease III like 1 (E. coli) antibody NTH endonuclease III Like 1 antibody NTH1 antibody NTHL 1 antibody Nthl1 antibody NTHL1_HUMAN antibody OCTS 3 antibody OCTS3 antibody
  • Application: WB,IHC-P
  • Epitope Region: Recombinant protein within human NTH1 aa 1-150/312.
  • Protein Target: NTHL1
  • Target Species: Human
  • Species Reactivity: Human