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24748

Urocortin III (human) (trifluoroacetate salt)

Cayman Chemical

- Open Babel Depiction O NH CH 3 S O NH O NH 2 O NH O NH O HN O H 2 N O NH HN O O NH 2 O NH CH 3 H 3 C H 3 C O HN CH 3 O HN H 3 C OH H 2 N O HN O O NH 2 H 3 C CH 3 H 3 C HN H 3 C HO H 3 C CH 3 CH 3 O N H HO O O HN O N OH CH 3 CH 3 O N H O N H CH 3 CH 3 NH O NH H 3 C O N N H O H 3 C O NH H 3 C O HN H 3 C O NH O H 2 N O HN O H 2 N H 3 C O HN CH 3 HN HN CH 3 H 3 C O NH H 3 C S O NH O HN H 2 N H 3 C O NH O H 2 N H 2 N O N H CH 3 O N H O NH HN O NH H 3 C O O H 2 N O O O N H H 3 C CH 3 H 3 C HN NH 2 HN HN

DESCRIPTION

A neuropeptide hormone; selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CRF2α and mouse CRF2β (EC50s = 0.16 and 0.12 nM, respectively); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells; reduces food intake in a dose- and time-dependent manner in mice (MED = 0.3 nmol/animal); increases swimming time in a forced swim test in mice, indicating antidepressant-like activity

DETAILS

  • Inchi: InChI=1S/C185H307N53O50S2.C2HF3O2/c1-33-93(18)142(147(196)251)233-163(267)114(57-59-134(190)243)213-152(256)101(26)207-160(264)115(60-66-289-31)215-166(270)118(69-87(6)7)220-172(276)124(76-108-83-199-85-201-108)217-155(259)102(27)208-164(268)125(77-135(191)244)218-154(258)98(23)203-148(252)96(21)202-149(253)97(22)204-159(263)113(56-58-133(189)242)212-151(255)100(25)206-158(262)112(54-46-64-200-185(197)198)214-165(269)117(68-86(4)5)221-173(277)126(78-136(192)245)225-161(265)111(53-43-45-63-187)211-150(254)99(24)205-157(261)110(52-42-44-62-186)210-153(257)103(28)209-180(284)143(94(19)34-2)234-175(279)128(80-138(194)247)227-171(275)123(75-107-50-40-37-41-51-107)224-168(272)120(71-89(10)11)219-167(271)119(70-88(8)9)222-174(278)127(79-137(193)246)226-162(266)116(61-67-290-32)216-181(285)144(95(20)35-3)235-176(280)129(81-139(195)248)230-183(287)146(105(30)241)237-179(283)132-55-47-65-238(132)184(288)141(92(16)17)232-177(281)130(82-140(249)250)228-169(273)121(72-90(12)13)223-178(282)131(84-239)231-170(274)122(73-91(14)15)229-182(286)145(104(29)240)236-156(260)109(188)74-106-48-38-36-39-49-106;3-2(4,5)1(6)7/h36-41,48-51,83,85-105,109-132,141-146,239-241H,33-35,42-47,52-82,84,186-188H2,1-32H3,(H2,189,242)(H2,190,243)(H2,191,244)(H2,192,245)(H2,193,246)(H2,194,247)(H2,195,248)(H2,196,251)(H,199,201)(H,202,253)(H,203,252)(H,204,263)(H,205,261)(H,206,262)(H,207,264)(H,208,268)(H,209,284)(H,210,257)(H,211,254)(H,212,255)(H,213,256)(H,214,269)(H,215,270)(H,216,285)(H,217,259)(H,218,258)(H,219,271)(H,220,276)(H,221,277)(H,222,278)(H,223,282)(H,224,272)(H,225,265)(H,226,266)(H,227,275)(H,228,273)(H,229,286)(H,230,287)(H,231,274)(H,232,281)(H,233,267)(H,234,279)(H,235,280)(H,236,260)(H,237,283)(H,249,250)(H4,197,198,200);(H,6,7)/t93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104+,105+,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,141-,142-,143-,144-,145-,146-;/m0./s1
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Neuroendocrinology
  • Smiles: NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)C)=O)C)=O)C)=O)=O)C)=O)CC4=CN=CN4)=O)=O)CCSC)=O)C)=O)=O)=O.O=C(O)C(F)(F)F
  • Inchikey: ZMELYLRCZAEWRR-WABNFCLFSA-N
  • Cas Number: 357952-09-1
  • Formulation: A lyophilized powder
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C185H307N53O50S2 • XCF3COOH
  • Formula Weight: 4137.9
  • Shelf Life Days: 1460
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