Ribonuclease R (RNase R), from the RNR superfamily of E.coli, is a Mg2+-dependent 3'-5' exonuclease. RNA can be cleaved into dinucleotide and trinucleotide gradually from the 3'-5' direction by RNase R. RNase R can digest most of the linear RNA. However, it is difficult to digest circular RNA, lariat RNA and short double-stranded RNA molecules with less than 7 nucleotides of 3' end protrusion. RNase R is commonly used in gene expression and alternative splicing studies and digests linear RNA to enrich circular RNA or lariat RNA. This product is obtained using recombinant protein technology. Our manufacturing processes are following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing.