Anti-NQO1 Antibody [13A1]

DESCRIPTION

NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals and radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression and coordinated induction of NQO1. ARE activation by tert-butylhydroquinone is dependent on PI3-kinase, which lies upstream of Nrf2. Nrf2, c-Jun, Nrf1, Jun-B and Jun-D bind to the ARE and regulate expression and induction of NQO1 gene. Maf-Maf homodimers and possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE and do not repress NQO1 transcription.

DETAILS

Host: Mouse
Type: Primary
Uniprot: SwissProt: P15559 Human;SwissProt: P05982 Rat
Clone Id: 13A1
Clonality: Mouse monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: Azoreductase antibody Cytochrome b 5 reductase antibody DHQU antibody DIA 4 antibody DIA4 antibody Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) antibody Diaphorase (NADH/NADPH) antibody Diaphorase 4 antibody Dioxin inducible 1 antibody DT diaphorase antibody DT-diaphorase antibody DTD antibody Menadione reductase antibody NAD(P)H dehydrogenase [quinone] 1 antibody NAD(P)H dehydrogenase quinone 1 antibody NAD(P)H menadione oxidoreductase 1 dioxin inducible antibody NAD(P)H quinone dehydrogenase 1 antibody NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1 antibody NAD(P)H:menadione oxidoreductase 1 antibody NAD(P)H:Quinone acceptor oxidoreductase type 1 antibody NAD(P)H:quinone oxidoreductase 1 antibody NAD(P)H:quinone oxireductase antibody NMOR 1 antibody NMOR I antibody NMOR1 antibody NMORI antibody NQO 1 antibody NQO1 antibody NQO1_HUMAN antibody Phylloquinone reductase antibody QR 1 antibody QR1 antibody Quinone reductase 1 antibody
Application: WB,IHC-P
Epitope Region: Recombinant protein within Human NQO1 aa 1-285.
Protein Target: DTD, QR1, NQO1, DIA4, NMOR1
Target Species: Human,Rat
Species Reactivity: Human,Rat