11-077
Aloxistatin [E-64d]
ProSci
DESCRIPTION
Aloxistatin [E-64d] is a cell permeable irreversible inhibitor of lysosomal and cytosolic cysteine proteases cathepsin B an L, calpain 1/2, papain and has diverse biological activities. It is an ethyl ester form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L.
Aloxistatin has anticancer properties by inducing cell cycle arret at the G2/M phase in A431 human epidermoid carcinoma cells and as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It inhibits degradation of autophagic cargo inside autolysosomes.
It also shows neuroprotective and anti-malarial properties.
Since cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, aloxistatin treatment reduces cellular entry of SARS-CoV-2 pseudovirions and COVID-19. It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein incorporation into pseudotyped vesicular stomatitis virus (VSV) particles in Vero cells. Is has been applied in vitro in combination with the TMPRSS2 inhibitor camostat mesylate (Prod. No. AG-CR1-3716).
DETAILS
- Cas: 88321-09-9
- Rtecs: RR0404300
- Purity: greater than or equal to 95% (HPLC)
- Smiles: O=C(OCC)[C@H]1O[C@@H]1C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O
- Formula: C17H30N2O5
- Storage: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
- Identity: Determined by 1H-NMR.
- Shipping: Room Temp
- Inchi Key: SRVFFFJZQVENJC-IHRRRGAJSA-N
- Solubility: Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (5mg/ml).
- Physical State: Lyophilized
- Additional Names: E-64c ethyl ester; EP 453; EST; Loxistatin
- Predicted Molecular Weight: 342.4
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