mouse monoclonal IgG2a; Dok-7 Antibody (A-7) is an IgG2a κ mouse monoclonal Dok-7 antibody (also designated DOK7 antibody) that detects the Dok-7 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Dok-7 Antibody (A-7) is available as both the non-conjugated anti-Dok-7 antibody form, as well as multiple conjugated forms of anti-Dok-7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The downstream of kinase family (Dok1-7) are members of a class of "docking" proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) - recessively inherited disorders characterized by muscle weakness.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.