APEH Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 327
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: APEH
Other Names: Acylamino-acid-releasing enzyme, AARE, Acyl-peptide hydrolase, APH, Acylaminoacyl-peptidase, Oxidized protein hydrolase, OPH, APEH, D3F15S2, D3S48E, DNF15S2
Availability: 2 weeks
Bio Background: APEH is the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. APEH gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. The protein can play an important role in destroying oxidatively damaged proteins in living cells.
Bio References: Perrier,J., Giardina,T. Biol. Cell 94 (1), 45-54 (2002)Erlandsson,R., Boldog,F. Oncogene 6 (7), 1293-1295 (1991)Erlandsson,R., Bergerheim,U.S. Oncogene 5 (8), 1207-1211 (1990)
Primary Accession: P13798
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1255a was selected from the N-term region of human APEH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.