14-Deoxyandrographolide

DESCRIPTION

A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 µg/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model

DETAILS

Inchi: InChI=1S/C20H30O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h9,15-17,21-22H,1,4-8,10-12H2,2-3H3/t15-,16+,17-,19+,20+/m1/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology & Xenobiotic Metabolism|Organ- & System-Specific Toxicity|Hepatotoxicity
Smiles: C=C1CC[C@]2([H])[C@](C)(CO)[C@H](O)CC[C@@]2(C)[C@@H]1CCC3=CCOC3=O
Inchikey: GVRNTWSGBWPJGS-YSDSKTICSA-N
Cas Number: 4176-97-0
Formulation: A solid
Item Origin: Plant/Andrographis paniculata
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C20H30O4
Formula Weight: 334.5
Shelf Life Days: 1460