6145453-25mg 6145453-10mg
Rolipram
Biogems
DESCRIPTION
Rolipram is a selective Type 4 cyclic nucleotide phosphodiesterases (PDE4) inhibitor, affective isoform A over other isoforms. It is reported to inhibit inflammation and induces neural differentiation of bone marrow-derived mesenchymal stem cells.
DETAILS
- Purity: ≥98%
- Synonyms: ZK 62711, Rolipramum,
- Cas Number: 61413-54-5
- References: Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., ... & Ge, J. (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 341(6146), 651-654. Sommer, N., Löschmann, P. A., Northoff, G. H., Weller, M., Steinbrecher, A., Steinbach, J. P., ... & Dichgans, J. (1995). The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nature medicine, 1(3), 244. Semmler, J., Wachtell, H., & Endres, S. (1993). The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells. International journal of immunopharmacology, 15(3), 409-413.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
- Molecular Weight: 275.3
- Molecular Formula: C16H21NO3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3