mouse monoclonal IgG2b; SUV3 Antibody (E-1) is an IgG2b κ mouse monoclonal SUV3 antibody (also designated SUV3 antibody) that detects the SUV3 protein of mouse, rat and human origin by WB, IP, IF and ELISA. SUV3 Antibody (E-1) is available as both the non-conjugated anti-SUV3 antibody form, as well as multiple conjugated forms of anti-SUV3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. SUV3, also known as SUPV3L1 (suppressor of var1, 3-like 1), is a 786 amino acid protein that localizes to both the nucleus and the mitochondrial matrix and contains one helicase C-terminal domain, as well as one helicase ATP-binding domain. Expressed in a broad range of tissues, SUV3 interacts with HBXIP and functions as an ATPase DNA/RNA helicase that uses magnesium as a cofactor to catalyze the unwinding of DNA/RNA and RNA/RNA duplexes, thereby playing a role in DNA replication and transcriptional initiation. SUV3 exhibits optimal activity at a pH of 5 and, in addition to its helicase activity, is thought to protect cells from apoptosis and participate in maintaining mitochondrial homeostasis. The gene encoding SUV3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.