Tolebrutinib

DESCRIPTION

An irreversible inhibitor of BTK (IC50 = 1 nM); decreases the number of CD69+ B cells in isolated whole mouse blood (IC50 = 200 nM)

DETAILS

Inchi: InChI=1S/C26H25N5O3/c1-2-23(32)29-16-6-7-19(17-29)30-22-14-15-28-25(27)24(22)31(26(30)33)18-10-12-21(13-11-18)34-20-8-4-3-5-9-20/h2-5,8-15,19H,1,6-7,16-17H2,(H2,27,28)/t19-/m1/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Kinase Inhibitors|Tec Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity
Smiles: NC1=C2C(N([C@@]3([H])CN(CCC3)C(C=C)=O)C(N2C4=CC=C(C=C4)OC5=CC=CC=C5)=O)=CC=N1
Inchikey: KOEUOFPEZFUWRF-LJQANCHMSA-N
Cas Number: 1971920-73-6
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C26H25N5O3
Formula Weight: 455.5
Shelf Life Days: 1460