SID 3712249

DESCRIPTION

An inhibitor of miR-544 biogenesis; increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, HIF-1α, and ATM in MDA-MB-231, MCF-7, and MCF-10A cells under hypoxic conditions at 20 nM; induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner at 20 nM; enhances the senstivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to 5-FU-induced decreases in cell viability at 20 nM; reduces tumor growth in an MDA-MB-231 mouse xenograft model

DETAILS

Inchi: InChI=1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
Purity: ≥95%
Raptas: Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Tumor Microenvironment||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis
Smiles: NC1=NC(N2CCCC2)=C(C#N)C3=C1C(N)=NC(N4CCCC4)=C3
Inchikey: SSWVPYMSHHEYAB-UHFFFAOYSA-N
Cas Number: 522606-67-3
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C17H21N7
Formula Weight: 323.4
Shelf Life Days: 1460