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AF-200-21

Animal-Free Recombinant Human IL-21

PeproTech

DETAILS

  • Gene Id: 59067
  • Uniprot: Q9HBE4
  • Activity: Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x10^6 units/mg.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Apoptosis, Cancer, Immune System, Stem Cells and Differentiation, CAR T Cell
  • Alternative Names: Interleukin-21, Za11
  • Species of Origin: Human
  • Expression System Source: E.coli

DESCRIPTION

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naive B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gammac) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.