RAMP2 Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10266
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RAMP2
Other Names: Receptor activity-modifying protein 2, Calcitonin-receptor-like receptor activity-modifying protein 2, CRLR activity-modifying protein 2, RAMP2
Availability: 2 weeks
Bio Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Bio References: Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)Michou, L., et al. Clin. Exp. Rheumatol. 26(6):1083-1086(2008)Qi, T., et al. Mol. Pharmacol. 74(4):1059-1071(2008)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Kuwasako, K., et al. J. Biol. Chem. 275(38):29602-29609(2000)Aldecoa, A., et al. FEBS Lett. 471 (2-3), 156-160 (2000)
Primary Accession: O60895