TMPH-00259
Bovine coronavirus (strain Mebus) Spike glycoprotein (His)
TargetMol
DESCRIPTION
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.; mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.; Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
DETAILS
- Purity: 98%
- Category: Compound
- Molecular Weight: 24.7 kDa as predicted
Lead Time: 4 - 5 weeks
Sign in to view pricing