ARHB Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 388
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RHOB
Other Names: Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB
Availability: 2 weeks
Bio Background: ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Bio References: Adly, M.A., et al. J. Cutan. Pathol. 37(7):751-757(2010)Connolly, E.C., et al. Mol. Cancer Res. 8(5):691-700(2010)Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391(2):1182-1186(2010)Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Primary Accession: P62745