DESCRIPTION

• Tag: N-Fc
• Host: HEK293
• Size: 100ug
• Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
• Format: Powder
• Purity: 90%
• Storage: -20℃
• Category: Immune Checkpoint Proteins
• Molecule: LIGHT
• Accession: NP 003798.2
• Conjugate: Unconjugated
• Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Background: Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
• Exp Region: Asp 74 - Val 240
• Swiss-prot: O43557-1
• Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 82.6 kDa. The protein migrates as 116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
• Endotoxin Level: 1.0 EU per μg
• Molecular Weight: 82.6 kDa
• Shipping Condition: RT
• Species Reactivity: Human
• Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html