T60713
TK-129
TargetMol
DESCRIPTION
TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used in cardiovascular disease studies which reduce isoprenaline-induced myocardial remodelling and fibrosis in vivo as well as reduce ang II-induced activation of cardiac fibroblasts in vitro [1].
DETAILS
- Purity: 98%
- Smiles: #N/A
- Category: Compound
- Molecular Weight: 305.38
- Molecular Formula: C15H23N5O2
Lead Time: 4 - 5 weeks
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