1241454-5mg 1241454-1mg
LGK974
Biogems
DESCRIPTION
LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity.
DETAILS
- Purity: ≥98%
- Synonyms: LGK-974, WNT-974, LGK 974
- Cas Number: 1243244-14-5
- References: Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., ... & Li, J. (2013). Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proceedings of the National Academy of Sciences, 110(50), 20224-20229. Glackin, C. A. (2014). Targeting the Twist and Wnt signaling pathways in metastatic breast cancer. Maturitas, 79(1), 48-51. Pan, S., Cheng, D., Liu, J., Zhang, G., Hsieh, M. H., Ng, N., ... & Harris, J. L. (2014, August). Discovery of LGK974, a potent and selective Porcupine inhibitor targeting Wnt signaling. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 248). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
- Molecular Weight: 396.4
- Molecular Formula: C23H20N6O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4