BIX 01294

DESCRIPTION

BIX 01294 is a diazepin-quinazolinamine derivate and G9a and GLP histone methyltransferase inhibitor. It is reported to function by blocking the histone binding sites. BIX01294 modulates the epigenetic status of chromatin and has been used to improve the reprogramming efficiency of iPSC generation.

DETAILS

Purity: ≥98%
Synonyms: BIX01294, BIX-01294, BIX01294 hydrochloride hydrate
Cas Number: 1808255-64-2
References: Ling, B. M. T., Bharathy, N., Chung, T. K., Kok, W. K., Li, S., Tan, Y. H., ... & Taneja, R. (2012). Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proceedings of the National Academy of Sciences, 109(3), 841-846. Culmes, M., Eckstein, H. H., Burgkart, R., Nüssler, A. K., Guenther, M., Wagner, E., & Pelisek, J. (2013). Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294. European journal of cell biology, 92(2), 70-79. Chang, Y., Zhang, X., Horton, J. R., Upadhyay, A. K., Spannhoff, A., Liu, J., ... & Cheng, X. (2009). Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Structural and Molecular Biology, 16(3), 312.
Application: FA
Formulation: Crystalline solid
Chemical Name: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4a,8a-dihydroquinazolin-4-amine
Molecular Weight: 600
Molecular Formula: C28H38N6O2 3HCl xH2O
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.O.Cl.Cl.Cl