sc-271197 SAMPLE sc-271197
Promo Available
Scientist.com Supplier
IP3R-I (E-8)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG1; IP3R-I Antibody (E-8) is an IgG1 κ mouse monoclonal IP3R-I antibody (also designated INSP3R1, IP3R1, IP3R antibody, intracellular receptor for inositol 1,4,5-trisphosphate antibody, inositol 1,4,5-trisphosphate receptor antibody, endoplasmic reticulum calcium channel antibody, C-terminal calcium channel / N-terminal ligand-binding receptor for inositol 1,4,5-trisphosphate antibody, or exocrine secretion, energy metabolism and growth related antibody) that detects the IP3R-I protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. IP3R-I Antibody (E-8) is available as both the non-conjugated anti-IP3R-I antibody form, as well as multiple conjugated forms of anti-IP3R-I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5- triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: Q14643
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, IHC(P), ELISA
- Human Gene Id: 3708
- Mouse Gene Id: 16438
- Protein Target: IP3R-I
- Human Gene Name: ITPR1
- Mouse Gene Name: Itpr1
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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