Trilobatin

DESCRIPTION

A dihydrochalcone glucoside with diverse biological activities; reduces survival of Bel 7402 and HepG2 cancer cells at 100 μM; increases SOD and GPX activity (EC50 = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM, respectively) in rat liver homogenates; reduces hydrogen peroxide-induced cell death and production of mitochondrial ROS, prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and IDH2 in PC12 neuronal cells; inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM)

DETAILS

Inchi: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-12-7-14(25)17(15(26)8-12)13(24)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-23,25-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Glutathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase
Smiles: OC1=CC=C(CCC(C2=C(O)C=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C2O)=O)C=C1
Inchikey: GSTCPEBQYSOEHV-QNDFHXLGSA-N
Cas Number: 4192-90-9
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C21H24O10
Formula Weight: 436.4
Shelf Life Days: 1460