863A-GB3Ct 863A-GB3C
Promo Available
Anti-GABAA Receptor ß3 Antibody
PhosphoSolutions
DESCRIPTION
Our Anti-GABAA Receptor ß3 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAA Receptor ß3 and is antigen affinity purified from pooled serum. It is great for use in WB, IHC.
DETAILS
- Form: Antigen Affinity Purified from Pooled Serum
- Gene: GABRB3
- Host: Rabbit
- Rrid: AB_2650497
- Type: Primary Antibody
- Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
- Target: GABAA Receptor ß3
- Isotype: IgG
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: ECA5 antibody, GABA alpha receptor beta-2 subunit antibody, GABA(A) receptor subunit beta-3 antibody, GABAA receptor beta 3 subunit antibody, GABAA receptor subunit beta 3 antibody, GABR B3 antibody, Gabrb3 antibody, Gamma aminobutyric acid (GABA) A receptor beta 3 antibody, Gamma aminobutyric acid receptor subunit beta 3 antibody, Gamma-aminobutyric acid receptor subunit beta-3 antibody, GBRB3_HUMAN antibody, MGC9051 antibody
- Clonality: Polyclonal
- Immunogen: Fusion protein from the cytoplasmic loop of the beta 3 subunit of rat GABAA receptor.
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Specific for endogenous levels of the ~53 kDa β3-subunit of the GABAA receptor.
- Applications: WB, IHC
- Ncbi Gene Id: 24922
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 53
- Production Notes: Prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
- Dilution Range Wb: 1:1000
- Immunogen Species: Rat
- Dilution Range Ihc: 1:300
- Species Reactivity: Mouse and Rat
- Target Description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
- Dilution Range Wb Brain: 1:1000
- Uniprot Number Immunogen Species: P63079
PROMOTION TERMS
Trial Size Available. Limit 1
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