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T83670

F1 TFA

TargetMol

- Open Babel Depiction O NH 2 OH O N H NH H 3 C CH 3 O HN O N H NH O NH 2 N H O NH HN NH 2 HN O N H O CH 3 CH 3 O HN O N H O OH CH 3 CH 3 CH 3 HO CH 3 CH 3 O NH H 3 C O NH H 2 N NH O HN O CH 3 CH 3 N H O CH 3 H 3 C NH N NH 2 NH 2 NH O S N H O CH 3 HN O CH 3 CH 3 N H O OH HN O HN NH H 2 N NH O O N H HN NH 2 NH O HN HN NH 2 N H O HN H 3 C NH H 2 N N H O NH 2 O NH

DESCRIPTION

F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectively blocks LPS-induced phosphorylation of IκB kinase α (IKKα) and IKKβ, along with the nuclear translocation of NF-κB (p65) in mouse peritoneal macrophages at 5 µM concentration. F1, administered at 5 mg/kg in vivo, significantly reduces IL-6, TNF-α, and IL-1β serum levels and enhances survival in a mouse sepsis model induced by LPS.

DETAILS

  • Purity: 98%
  • Smiles: [H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC1=CC=C(O)C=C1)N[H])=O)=O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@]([H])([C@@H](C)O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
  • Category: Compound
  • Molecular Weight: 3189.88
  • Molecular Formula: C145H246N48O31S.XCF3COOH

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