T83670
F1 TFA
TargetMol
DESCRIPTION
F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectively blocks LPS-induced phosphorylation of IκB kinase α (IKKα) and IKKβ, along with the nuclear translocation of NF-κB (p65) in mouse peritoneal macrophages at 5 µM concentration. F1, administered at 5 mg/kg in vivo, significantly reduces IL-6, TNF-α, and IL-1β serum levels and enhances survival in a mouse sepsis model induced by LPS.
DETAILS
- Purity: 98%
- Smiles: [H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC1=CC=C(O)C=C1)N[H])=O)=O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@]([H])([C@@H](C)O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
- Category: Compound
- Molecular Weight: 3189.88
- Molecular Formula: C145H246N48O31S.XCF3COOH
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