(S)-Crizotinib

DESCRIPTION

An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg

DETAILS

Inchi: InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair
Smiles: FC1=CC=C(Cl)C([C@H](C)OC2=CC(C3=CN(C4CCNCC4)N=C3)=CN=C2N)=C1Cl
Inchikey: KTEIFNKAUNYNJU-LBPRGKRZSA-N
Cas Number: 1374356-45-2
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C21H22Cl2FN5O
Formula Weight: 450.3
Shelf Life Days: 1460