6563252-25mg 6563252-5mg
Reversine
Biogems
DESCRIPTION
Reversine is a potent adenosine A3 receptor, MEK1, and Aurora B kinase inhibitor. It is reported to be used to de-differentiate myoblasts to stem cell progenitors with adipogenic and osteogenic potential. Reversine is also used to selectively induce cell death in cancer cells
DETAILS
- Purity: ≥98%
- Synonyms: 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine, CHEMBL188343
- Cas Number: 656820-32-5
- References: Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E. C., ... & Schultz, P. G. (2007). Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences, 104(25), 10482-10487. D'Alise, A. M., Amabile, G., Iovino, M., Di Giorgio, F. P., Bartiromo, M., Sessa, F., ... & Cortese, R. (2008). Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Molecular cancer therapeutics, 7(5), 1140-1149. Anastasia, L., Sampaolesi, M., Papini, N., Oleari, D., Lamorte, G., Tringali, C., ... & Venerando, B. (2006). Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death & Differentiation, 13(12), 2042-2051.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
- Molecular Weight: 393.5
- Molecular Formula: C21H27N7O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5