mouse monoclonal IgG2b; PXDN Antibody (2C11) is an IgG2b κ mouse monoclonal PXDN antibody (also designated PXDN antibody) that detects the PXDN protein of human origin by WB, IP and ELISA. PXDN Antibody (2C11) is available as the non-conjugated anti-PXDN antibody. PXDN (peroxidasin homolog), also known as PXN, VPO (vascular peroxidase 1), PRG2 (p53-responsive gene 2 protein) or MG50 (melanoma-associated gene 50), is a 1,479 amino acid secreted protein that is highly expressed in heart, lung, ovary, spleen, intestine and placenta, and lowly expressed in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Belonging to the peroxidase family and the XPO subfamily, PXDN is suggested to participate in extracellular matrix formation. PXDN consists of four Ig-like C2-type (immunoglobulin-like) domains, four LRR (leucine-rich repeats), one LRRCT domain, one LRRNT domain and a VWFC domain. PXDN may exist as two alternatively isoforms and as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins.