TMPY-02650
Alkaline phosphatase Protein, Human, Recombinant (His)
TargetMol
DESCRIPTION
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.
DETAILS
- Purity: 98.4%
- Category: Compound
- Molecular Weight: Approxiamtely 54 kDa
Lead Time: 4 - 5 weeks
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