35494
PKCβ Inhibitor
Cayman Chemical
DESCRIPTION
A PKCβ Inhibitor (IC50s = 21 and 5 nM, respectively); selective for PKCβ1 and PKCβ2 over PKCα, PKCε, and PKCγ (IC50s = 331, 2,807, and >1,000 nM, respectively), as well as JAK1, JAK2, and TYK2 (IC50s = 770, 3,850, and 2,310 nM, respectively); inhibits JAK3 (IC50 = 17 nM); induces apoptosis and inhibits cell cycle progression in 2F7 AIDS-related Burkitt's lymphoma cells at 14 µM
DETAILS
- Inchi: InChI=1S/C24H21N5O2/c30-23-21(22(24(31)27-23)26-17-7-2-1-3-8-17)19-15-29(20-10-5-4-9-18(19)20)13-6-12-28-14-11-25-16-28/h1-5,7-11,14-16H,6,12-13H2,(H2,26,27,30,31)
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PKC Signaling
- Smiles: O=C1NC(C(C2=CN(CCCN3C=NC=C3)C4=C2C=CC=C4)=C1NC5=CC=CC=C5)=O
- Inchikey: KIWODJBCHRADND-UHFFFAOYSA-N
- Cas Number: 257879-35-9
- Formulation: A solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C24H21N5O2
- Formula Weight: 411.5
- Shelf Life Days: 1460