2256236-10mg 2256236-1mg
1-Oleoyl Lysophosphatidic Acid (sodium salt)
Biogems
DETAILS
- Purity: ≥95%
- Synonyms: 9-Octadecenoicacid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 1-oleoyl sodium salt, LPA sodium salt
- Cas Number: 22556-62-3
- References: McIntyre, T. M., Pontsler, A. V., Silva, A. R., Hilaire, A. S., Xu, Y., Hinshaw, J. C., ... & Prestwich, G. D. (2003). Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist.Proceedings of the National Academy of Sciences, 100(1), 131-136. Dottori, M., Leung, J., Turnley, A. M., & Pebay, A. (2008). Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells, 26(5), 1146-1154. Lapierre, D. M., Tanabe, N., Pereverzev, A., Spencer, M., Shugg, R. P., Dixon, S. J., & Sims, S. M. (2010). Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. Journal of Biological Chemistry, 285(33), 25792-25801.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: [2-hydroxy-3-(octadec-9-enoyloxy)propoxy]phosphonic acid sodium
- Molecular Weight: 458.5
- Molecular Formula: C21H40O7P Na
- Storage Conditions: Product should be kept at-20°C.
- Pubchem Openeye Can Smiles: CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)[O-])O.[Na+]
DESCRIPTION
1-Oleoyl Lysophosphatidic Acid is a lysophophatidic acid (LSA) with oleic acid in the sn-1 position that is an endogenous agonist for LPA1 and LPA2 receptors. It is reported to inhibit the differentiation of neural stem cells into neurons and is involved in multiple biological activities such as smooth muscle contraction, platelet aggregation, cell proliferation, cell migration, and calcium mobilization. 1-Oleoyl Lysophosphatidic Acid is commonly used for growth stimulation in a variety of cell lines.