mouse monoclonal IgG1; M-RIP Antibody (E-1) is an IgG1 κ mouse monoclonal M-RIP antibody (also designated M-RIP antibody) that detects the M-RIP protein of mouse, rat and human origin by WB, IP, IF and ELISA. M-RIP Antibody (E-1) is available as both the non-conjugated anti-M-RIP antibody form, as well as multiple conjugated forms of anti-M-RIP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. M-RIP (myosin phosphatase Rho interacting protein), also known as MPRIP, p116Rip, RIP3 or RHOIP3, is a 1,025 amino acid cytoplasmic and cytoskeletal protein that is required for regulation of the actin cytoskeleton. M-RIP colocalizes with myosin binding subunit (MBS) to regulate the phosphorylation of myosin light chain, and colocalizes with F-actin through its N-terminus in the cytoskeleton. M-RIP also interacts with and RhoA at actin stress fibers via its adjacent coiled coil domains. M-RIP is highly expressed in ovary, with moderate levels found in brain, heart, liver, lung, skeletal muscle, testis and kidney. M-RIP depletion causes an increase of stress fibers in smooth muscle cells, whereas M-RIP over-expression causes disassembly of stress fibers in neuronal cells. Containing two PH domains, M-RIP has multiple phosphorylated serine and threonine residues and exists as three isoforms which are produced by alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.