1524762-50mg 1524762-5mg
SB 203580
Biogems
DESCRIPTION
SB 203580 is a p38 specific inhibitor that prevents the downstream activation of heat shock protein 27 and MAP kinase-activated protein kinase 2 (MAPKAPK2). It can have anti-proliferative activity on cytokine-activated lymphocytes and is reported to be used to enhance cardiomyocyte differentiation.
DETAILS
- Purity: ≥98%
- Synonyms: SB203580, RWJ 64809, CHEMBL10, CTK8E9223
- Cas Number: 152121-47-6
- References: Lali, F. V., Hunt, A. E., Turner, S. J., & Foxwell, B. M. (2000). The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. Journal of Biological Chemistry, 275(10), 7395-7402. Barancik, M., Htun, P., Strohm, C., Kilian, S., & Schaper, W. (2000). Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death.Journal of cardiovascular pharmacology, 35(3), 474-483. Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., & Marber, M. S. (2001). Antiischemic Effects of SB203580 Are Mediated Through the Inhibition of p38α Mitogen-Activated Protein Kinase Evidence From Ectopic Expression of an Inhibition-Resistant Kinase. Circulation research, 89(9), 750-752.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
- Molecular Weight: 377.4
- Molecular Formula: C21H16FN3OS
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F