HPI-1

DESCRIPTION

HPI-1 is a hedgehog (Hh) signaling inhibitor without significantly effecting Wnt signaling. It inhibits Gli1 and Gli2 induced activation and the proliferation of SmoM2 expressing cell lines.

DETAILS

Purity: ≥95%
Synonyms: ST093553, AC1MFWGY, Hedgehog pathway inhibitor 1
Cas Number: 599150-20-6
References: Xu, Y., Chenna, V., Hu, C., Sun, H. X., Khan, M., Bai, H., ... & Anders, R. A. (2012). Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clinical Cancer Research, 18(5), 1291-1302. Hyman, J. M., Firestone, A. J., Heine, V. M., Zhao, Y., Ocasio, C. A., Han, K., ... & Chen, J. K. (2009). Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences, 106(33), 14132-14137. Merchant, A. A., & Matsui, W. (2010). Targeting Hedgehog—a cancer stem cell pathway. Clinical Cancer Research, 16(12), 3130-3140.
Application: FA
Formulation: Crystalline solid
Chemical Name: 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
Molecular Weight: 463.5
Molecular Formula: C27H29NO6
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC