10009610
Lomitapide
Cayman Chemical
DESCRIPTION
An MTTP inhibitor (IC50 = 0.5 nM in a triglyceride transfer assay); inhibits ApoB secretion in HepG2 cells (EC50 = 0.8 nM); inhibits triglyceride secretion in fasted rats (ED50 = 0.19 mg/kg, p.o.); reduces total plasma cholesterol levels in hamsters (ED50 = 2.4 mg/kg); decreases plasma cholesterol and triglyceride levels in the WHHL rabbit model of homozygous familial hypercholesterolemia at 10 mg/kg
DETAILS
- Inchi: InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Lipid Biochemistry|Sterol Lipids
- Smiles: O=C(NCC(F)(F)F)C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C=CC=C5)C6=C1C=CC=C6
- Inchikey: MBBCVAKAJPKAKM-UHFFFAOYSA-N
- Cas Number: 182431-12-5
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C39H37F6N3O2
- Formula Weight: 693.7
- Shelf Life Days: 1460