SPC-600D-RPE
Beclin 1 Antibody: RPE
Stressmarq Biosciences
DESCRIPTION
Rabbit Anti-Human Beclin 1 Polyclonal
DETAILS
- Target: Beclin 1
- Gene Id: 8678
- Conjugate: RPE
- Immunogen: Synthetic peptide from the mid-protein of human Beclin 1
- References: 1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.
- Swiss-prot: Q14457
- Specificity: Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.
- Applications: WB | ICC/IF
- Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Host Species: Rabbit
- Product Type: Polyclonal
- Purification: Peptide Affinity Purified
- Concentration: 1 mg/ml
- Research Areas: Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Cancer | Tumor suppressors | Cancer | Autophagy | Cancer | Cancer Metabolism
- Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
- Accession Number: NP_001300927.1
- Alternative Names: APG6 Antibody, BCL-2 interacting protein beclin Antibody, Beclin 1 autophagy related Antibody, BECN1 Antibody, BECN1_HUMAN Antibody, GT197 Antibody, VPS30 Antibody
- Antibody Dilution: WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
- Cite This Product: StressMarq Biosciences Cat# SPC-600D-RPE, RRID: AB_2704725
- Immunogen Species: Human
- Storage Temperature: Conjugated antibodies should be stored according to the product label
- Shipping Temperature: Blue Ice or 4ºC
- Cellular Localization: Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome
- Scientific Background: Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).
- Certificate of Analysis: A 1:1000 dilution of SPC-600 was sufficient for detection of Beclin1 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Species Reactivity Full Name: Human | Rat
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