Skip to Main Content
Welcome to the Scientist.com Marketplace

Go to Main Navigation

SPC-600D-RPE

Beclin 1 Antibody: RPE

Stressmarq Biosciences

DESCRIPTION

Rabbit Anti-Human Beclin 1 Polyclonal

DETAILS

  • Target: Beclin 1
  • Gene Id: 8678
  • Conjugate: RPE
  • Immunogen: Synthetic peptide from the mid-protein of human Beclin 1
  • References: 1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.
  • Swiss-prot: Q14457
  • Specificity: Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.
  • Applications: WB | ICC/IF
  • Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
  • Host Species: Rabbit
  • Product Type: Polyclonal
  • Purification: Peptide Affinity Purified
  • Concentration: 1 mg/ml
  • Research Areas: Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Cancer | Tumor suppressors | Cancer | Autophagy | Cancer | Cancer Metabolism
  • Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
  • Accession Number: NP_001300927.1
  • Alternative Names: APG6 Antibody, BCL-2 interacting protein beclin Antibody, Beclin 1 autophagy related Antibody, BECN1 Antibody, BECN1_HUMAN Antibody, GT197 Antibody, VPS30 Antibody
  • Antibody Dilution: WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
  • Cite This Product: StressMarq Biosciences Cat# SPC-600D-RPE, RRID: AB_2704725
  • Immunogen Species: Human
  • Storage Temperature: Conjugated antibodies should be stored according to the product label
  • Shipping Temperature: Blue Ice or 4ºC
  • Cellular Localization: Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome
  • Scientific Background: Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).
  • Certificate of Analysis: A 1:1000 dilution of SPC-600 was sufficient for detection of Beclin1 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
  • Species Reactivity Full Name: Human | Rat