PV3-H5255-100ug PV3-H5255-1mg
Human Nectin-3 / CD113 Protein, Fc Tag
ACROBiosystems
DESCRIPTION
Human Nectin-3, Fc Tag (PV3-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 58 - Asp 400 (Accession # Q9NQS3).
DETAILS
- Tag: C-Fc
- Host: HEK293
- Size: 100ug
- Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
- Format: Powder
- Purity: 95%
- Storage: -20℃
- Category: Immune Checkpoint Proteins
- Molecule: Nectin-3
- Accession: Q9NQS3
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Background: Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
- Exp Region: Gly 58 - Asp 400
- Swiss-prot: NP_056295.1
- Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 64.3 kDa
- Shipping Condition: RT
- Species Reactivity: Human
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