Anti-Integrin β1 (Extracellular region) Antibody

DETAILS

Form: Protein G Purified
Gene: ITGB1
Host: Mouse
Rrid: AB_3068458
Type: Primary Antibody
Clone: M032
Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Target: Integrin β1 (Extracellular region)
Isotype: IgG1
Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Shipping: Blue Ice
Synonyms: Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, TGB1, FNRB, MDF2, MSK12, ITGB1
Clonality: Mouse Monoclonal
Immunogen: Clone M032 was generated from a proprietary antigen related to the extracellular region of human integrin β1 expressed in A431 epidermoid carcinoma cell line.
Expiration: After date of receipt, stable for at least 1 year at -20°C.
Specificity: Clone M032 detects a 120-150 kDa* band corresponding to Integrin β1 on SDS-PAGE immunoblots of "Native" human A431, A549, MDA-MB-231, and LNCaP cell lysates, as well as human breast, skin, and lung tissues. The antibody weakly detects the denatured form of Integrin β1. Clone M032 can be used in western blot, immunocytochemistry, and ELISA.
Applications: WB, ICC
Conjugate Exem: Unconjugated
Physical State: Liquid
Quality Control: Western blots performed on each lot.
Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Molecular Weight: 120-150
Dilution Range Wb: 1:500
Immunogen Species: Human
Dilution Range Icc: 1:200
Species Reactivity: Human
Target Description: Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β2 subunit associates with integrin αL to form a receptor for ICAM family members. Integrin β2/αL is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Uniprot Number Immunogen Species: P05556