sc-398595 SAMPLE sc-398595
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Fos B (F-7)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG1; Fos B Antibody (F-7) is an IgG1 κ mouse monoclonal Fos B antibody that detects the Fos B protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Fos B Antibody (F-7) is available as both the non-conjugated anti-Fos B antibody form, as well as multiple conjugated forms of anti-Fos B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPAresponse elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: P53539
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, IHC(P), ELISA
- Human Gene Id: 2354
- Mouse Gene Id: 14282
- Protein Target: Fos B
- Human Gene Name: FOSB
- Mouse Gene Name: Fosb
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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