4-Hydroxyisoleucine

DESCRIPTION

An amino acid with antidiabetic activity; increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas at 200 μM; increases PI3K activity in muscle and liver in rats at 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and STZ at 25 mg/kg; decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes at 50 mg/kg per day for four weeks

DETAILS

Inchi: InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5?/m0/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Amino Acids|Natural||Product Type|Biochemicals|Natural Products||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
Smiles: C[C@H](O)[C@H](C)[C@H](N)C(O)=O
Inchikey: OSCCDBFHNMXNME-QRHDOFTISA-N
Cas Number: 55399-93-4
Formulation: A solid
Item Origin: Synthetic
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C6H13NO3
Formula Weight: 147.2
Shelf Life Days: 1460