2885842-1g 2885842-100mg
IBMX
Biogems
DESCRIPTION
IBMX is a general inhibitor of cyclic nucleotide phosphodiesterases, increasing the level of intracellular cAMP. It is used to increase cell differentiation, decrease proliferation, and induce apoptosis. IBMX is reported to inhibit TNF-alpha, reduce inflammation, and activate PKA.
DETAILS
- Purity: ≥98%
- Synonyms: 1-Methyl-3-isobutylxanthine, 3-Isobutyl-1-methylxanthine, Isobutyltheophylline
- Cas Number: 28822-58-4
- References: Usachev, Y., & Verkhratsky, A. (1995). IBMX induces calcium release from intracellular stores in rat sensory neurones. Cell calcium, 17(3), 197-206. Tio, M., Tan, K. H., Lee, W., Wang, T. T., & Udolph, G. (2010). Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One, 5(2), e9398. Hube, F., Lee, Y. M., Röhrig, K., & Hauner, H. (1999). The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect. Hormone and metabolic research= Hormon-und Stoffwechselforschung= Hormones et metabolisme,31(6), 359-362.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
- Molecular Weight: 222.3
- Molecular Formula: C10H14N4O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2