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S1D-C52Hc-100ug S1D-C52Hc-1mg

SARS-CoV-2 S1 protein NTD (L18F, D80A, D215G, 242-244del, R246I), His Tag (MALS verified)

ACROBiosystems

DESCRIPTION

SARS-CoV-2 S1 protein NTD, His Tag (S1D-C52Hc) is expressed from human 293 cells (HEK293). It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1). The L18F/D80A/D215G/LAL242-244del/R246I mutations were identified on the spike protein N-terminal domain (NTD) in the SARS-CoV-2 Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2).

DETAILS

  • Tag: C-10×His
  • Host: HEK293
  • Size: 100ug
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 90%
  • Storage: -20℃
  • Category: Viral Proteins
  • Molecule: Spike NTD
  • Accession: QHD43416.1
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Exp Region: Ser 13 - Leu 303
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 34.5 kDa
  • Shipping Condition: RT
  • Species Reactivity: SARS-CoV-2
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html