Anti-ILF3 Antibody [JG37-63]

DESCRIPTION

ILF3 (interleukin enhancer binding factor 3) or TCP80 (translational control protein 80), is a ubiquitously expressed nuclear protein that exists in a heterodimer with NF45. NF90 contains two DRBM (double-stranded RNA(dsRNA-)-binding) domains and one DZF domain and, in association with NF45 primarily participates in the regulation of IL-2 expression by binding to the antigen receptor response element (ARRE) target sequence of the IL-2 enhancer. In neuronal cells, the NF45/NF90 heterodimer can repress human rhinovirus type 2 replication by binding to a 5' untranslated region of the viral RNA that encodes the internal ribosome entry site (IRES). NF45 and NF90 belong to the double-stranded RNA-binding protein family and both are substrates for the dsRNA-activated protein kinase, PKR. Due to alternative splicing events, six isoforms exist for NF90, namely NFAR-2 (or ILF3-E), NFAR-1 (or DRBP76), isoform 3, DRBP76α (or ILF3-A), DRBP76δ (also known as DRBP76γ or ILF3-C) and isoform 6.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: Q12906 Human;SwissProt: Q9Z1X4 Mouse;SwissProt: Q9JIL3 Rat
Clone Id: JG37-63
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: CBTF antibody Double stranded RNA binding protein 76 antibody Double-stranded RNA-binding protein 76 antibody DRBF antibody DRBP76 antibody ILF3 antibody ILF3_HUMAN antibody Interleukin enhancer binding factor 3 antibody Interleukin enhancer-binding factor 3 antibody M phase phosphoprotein 4 antibody M-phase phosphoprotein 4 antibody MPHOSPH4 antibody MPP4 antibody NF AT 90 antibody NF-AT-90 antibody NF110 antibody NF90 antibody NFAR antibody Nuclear factor associated with dsRNA antibody Nuclear factor of activated T cells 90 kDa antibody Nuclear factor of activated T-cells 90 kDa antibody TCP80 antibody Translational control protein 80 antibody
Application: WB,IP,IF-Cell,IF-Tissue,IHC-P,FC
Epitope Region: Synthetic peptide within Human ILF3 aa 2-51 / 894.
Protein Target: DRBP76, MPP4, NFAR, NF-AT-90, TCP80, ILF3
Target Species: Human,Mouse,Rat
Species Reactivity: Human,Mouse,Rat