mouse monoclonal IgG2a; XPC Antibody (D-10) is an IgG2a κ mouse monoclonal XPC antibody (also designated XPC antibody, DNA Damage Recognition And Repair Factor antibody, XPCC antibody, Xeroderma Pigmentosum Complementation Group C antibody, DNA Repair Protein Complementing XP-C Cells antibody, RAD4 antibody, P125 antibody, or XP3 antibody) that detects the XPC protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. XPC Antibody (D-10) is available as both the non-conjugated anti-XPC antibody form, as well as multiple conjugated forms of anti-XPC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair (NER) proteins. NER provides versatile DNA repair mechanisms to en-sure the proper functioning of all cells. The majority of patients with XP carry mutations in either the XPA or XPC genes, which encode proteins involved in the recognition of damaged DNA. The gene encoding human XPC maps to chromosome 3p25. XPC forms a complex with Cen2 and the human homolog of yeast Rad23B (HR23B), both of which stabilize XPC; it also excises thymine dimers from damaged DNA. Specifically, the carboxy-terminus of XPC is re-quired for HR23B and DNA binding and, subsequently, mutations leading to carboxy-terminal truncations result in nonfunctional XPC proteins.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.