36-1782
Monoclonal Antibody to Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(Clone : TYRP1/807)
Abeomics
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DESCRIPTION
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
DETAILS
- Gene: TYRP1
- App Id: IHC
- Antigen: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)
- Gene Id: 7306
- Isotype: Mouse IgG2a, kappa
- Format Id: Purified
- Clone Name: TYRP1/807
- Uniprot Id: P17643
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Affinity Chromatography
- Reactivity Id: Human, Mouse
- Product Content: 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
- Alternative Name: TYRP1||CAS2||TYRP||TYRRP
- Application Note: Immunohistochemistry (Formalin-fixed) (3-6ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
- Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Recombinant full-length human TYRP1 protein