E6558Hu
Human Bile Salt Export Pump, ABCB11 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132).
Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).
Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269).
DETAILS
- Gene Id: 8647
- Uniprot: O95342
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 9.52ng/L
- Detection Range: 20-4500ng/L
- Detection Method: ELISA
- Species Reactivity: Human