Skip to Main Content
Welcome to the Scientist.com Marketplace

Go to Main Navigation

E6558Hu

Human Bile Salt Export Pump, ABCB11 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269).

DETAILS

  • GeneID: 8647
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 146,407
  • Synonyms: ABC16;ABCB11;ATP-binding cassette sub-family B member 11;Bile salt export pump;BRIC2;BSEP;PFIC2;PGY4;SPGP;
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: ABCB11
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 9.52ng/L
  • Target Protein: ABCB11
  • Detection Range: 20-4500ng/L
  • Full Product Name: Bile salt export pump
  • Standard Solution: 4800ng/L
  • UniProt Accession: O95342