29719
PD 082106
Cayman Chemical
DESCRIPTION
An inhibitor of FLT3 kinase (IC50 = 0.015 µM); selective for FLT3 over Met, Ron, EGFR, and the insulin receptor (IC50s = >10 µM for all) but does inhibit DRAK2 (IC50 = 0.62 µM), as well as VEGFR2 and Aurora A (IC50s = 1.53 and 1.27 µM, respectively); inhibits proliferation of A549, SNU-638, HT-1080, HL-60, and MCF-7 cancer cells (IC50s = 13, 2.1, 3.4, 89, and 9 µM, respectively); inhibits proliferation of (IC50 = 5.1 µM), and induces apoptosis in, RK3E-ras cells and reduces tumor growth in RK3E-ras flank and oral tumor models; active against the parasite T. gondii (ID50 = 0.52 µM) with a TD50 value of 61 µM
DETAILS
- Inchi: InChI=1S/C16H10FN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Toxoplasmosis
- Smiles: FC1=CC=C2C(/C(C(N2)=O)=C3\C(C(C=CC=C4)=C4N3)=N\O)=C1
- Inchikey: RJIBTAMXAXHIAN-WAVHTBQISA-N
- Cas Number: 861214-33-7
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C16H10FN3O2
- Formula Weight: 295.3
- Shelf Life Days: 1460