mouse monoclonal IgG1; HGFA Antibody (B-6) is an IgG1 κ mouse monoclonal HGFA antibody (also designated HGFA antibody) that detects the HGFA protein of mouse, rat and human origin by WB, IP, IF and ELISA. HGFA Antibody (B-6) is available as both the non-conjugated anti-HGFA antibody form, as well as multiple conjugated forms of anti-HGFA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Hepatocyte growth factor (HGF) is a pleiotropic growth factor variously designated scatter factor, hematopoietin A and mammary growth factor. HGF is synthesized as a single chain, 728 amino acid precursor with a 29 amino acid signal peptide which is not present in the mature protein. Biologically active HGF is composed of a disulfide-linked a chain and a b chain, both of which are highly glycosylated. HGF exerts its biological effects through the HGF receptor, c-Met, which is expressed in ovary and endometrial endothelium and in the basal layers of skin. Hepatocyte growth factor activator (HGFA) is a serine protease which functions to cleave single chain HGF to its active heterodimeric form. HGFA is specific to the liver. HGFA of human origin is synthesized as an inactive secreted 655 amino acid precursor which is activated to generate a heterodimer consisting of a 35 amino acid short chain and a 248 amino acid long chain linked together by a disulfide bond. The gene encoding HGFA maps to human chromosome 4p16.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.